![]() Prescriptions for sleep medications have increased. During the COVID-19 pandemic, the effects on sleep have been significant, particularly insomnia. Seeking inpatient admission for her insomnia. Insomnia caused severe impairment of her daily life activities to a point where she was almost ![]() She had no mood disorders or psychosocial stressors, and the patient had excellent sleep hygiene measures. However, magnetic resonance imaging (MRI) brain imaging only showed nonspecific white matter disease. Her insomnia was resistant to multiple medications including zolpidem Immediate-release(IR), Controlled-release(CR) formulas, zaleplon, eszopiclone, trazodone, melatonin, clonazepam, suvorexant, and lemborexant. Immediately following the vaccination, the patient had severe trouble falling and stayingĪsleep. The patient finished her two-shot series of the Moderna COVID-19 vaccine in April 2021. She had a history of COVID infection in November 2020 with only mild symptoms of sore throat and fatigue. Report of Cases: A 59-year-old female with a past medical history of well-controlled hypothyroidism and migraine presented to the sleep center with four months of insomnia. ![]() We present a rare case of severe insomnia as a long-term side effect following COVID-19 vaccination. In addition, there have been few reported long-term side effects, including Guillain-Barre, pericarditis, and cerebral venous sinus thrombosis. The COVID-19 vaccines have documented transient side effects, including injection site soreness, redness, headache, fatigue, and fever.
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